From Limbs to Lungs: A Newt Perspective on Compensatory Lung Growth.
نویسندگان
چکیده
Partial lung resection initiates compensatory growth of remaining lobes to restore pulmonary structure and function. Mechanisms underlying this response are not well defined. This article considers molecular pathways involved in control of amphibian limb regeneration and tissue pattern formation for novel insight into the understanding of compensatory lung growth.
منابع مشابه
Induction of Compensatory Lung Growth in Pulmonary Emphysema Improves Surgical Outcomes in Rats Running Head: HGF for Lung Volume Reduction Surgery
Rationale and Objectives Although lung volume reduction surgery (LVRS) has been widely employed as a therapeutic strategy for pulmonary emphysema, the procedure carries significant disadvantages, including significant operative mortality and a limited duration of effective response. Pulmonary resection is known to elicit compensatory growth in remnant lung tissues, however, it remains unclear w...
متن کاملInduction of compensatory lung growth in pulmonary emphysema improves surgical outcomes in rats.
RATIONALE AND OBJECTIVES Although lung volume reduction surgery (LVRS) has been widely used as a therapeutic strategy for pulmonary emphysema, the procedure carries significant disadvantages, including significant operative mortality and a limited duration of effective response. Pulmonary resection is known to elicit compensatory growth in remnant lung tissues; however, it remains unclear wheth...
متن کاملNeoalveolarisation contributes to compensatory lung growth following pneumonectomy in mice.
Regeneration of the gas exchange area by induction of neoalveolarisation would greatly improve therapeutic options in destructive pulmonary diseases. Unilateral pneumonectomy is an established model to remove defined portions of gas exchange area and study mechanisms of compensatory lung growth. The question of whether new alveoli are added to the residual lung after pneumonectomy in mice was a...
متن کاملNeoalveolarization contributes to compensatory lung growth following pneumonectomy in mice
Regeneration of gas exchange area by induction of neoalveolarization would greatly improve therapeutic options in destructive pulmonary diseases. Unilateral pneumonectomy is an established model to remove defined portions of gas exchange area and study mechanisms of compensatory lung growth. We addressed the question whether new alveoli are added to the residual lung after pneumonectomy in mice...
متن کاملSupernumerary Limb Induction in Ambystoma Larvaeby Frog Tissue Implants
Pieces of kidney and/or lung from adult frog (Rana pipiens) when implanted under the dorsal skin of the lower arm (mid-radius/ulna level) of Ambystoma maculatum larvae, induced supernumerary limbs in over 75% of the cases. Liver was completely ineffective in inducing ability. However, liver did not lower the inducing capacity of lung in combination grafts. When the insertion hole was distal to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
دوره 14 شماره
صفحات -
تاریخ انتشار 1999